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Dyspepsia is gastric upset due to the inability to digest one’s food.
Dyspepsia is a word that has been used in English since the early eighteenth century not only for a variety of stomach ailments but also for bad moods or temper outbursts that were thought to be caused by indigestion. The English word comes from two Greek words meaning “hard or difficult’ and “digestion.’ For many years dyspepsia was a catchall term for any kind of stomach upset characterized by burning, nauseous, or gassy sensations in the upper abdomen. Several phrases that are still used almost interchangeably for the condition are gastric indigestion, nervous dyspepsia, and impaired gastric function.
Dyspepsia was not defined more closely until the mid-1980s, when an international group of gastroen-terologists (doctors who specialize in treating disorders of the digestive system) met in Rome to create a set of criteria for distinguishing dyspepsia from other disorders of the upper digestive tract (known as the Rome criteria); and to distinguish between organic dyspepsia—stomach upset that can be shown to have a physical cause (for example, stomach irritation caused by alcohol consumption), and functional dyspepsia (FD)—dyspepsia that cannot be traced to any specific physical cause. FD accounts for a majority of cases of dyspepsia, as many as 60% in some studies, and for 30–50% of all referrals from primary care doctors to gastroenterologists.
Dyspepsia is considered a difficult condition to treat, even though it is widespread in the general population. An estimated 25–40% of adolescents and.
adults in North America experience dyspepsia each year. Most people with the disorder do not seek medical treatment because it may be intermittent as well as persistent. FD is responsible for high health care costs in terms of prescription as well as over-the-counter medications, diagnostic tests, and time lost from work.
In the nineteenth and early twentieth centuries, FD was commonly treated with various forms of dietary therapies. Treatments commonly recommended by doctors in the 1920s included vegetarian diets as well as the use of laxatives and enemas to cure the patient of autointoxication—an imaginary disorder that originated in ancient Egypt and is based on the belief that the contents of the colon are toxic and capable of poisoning other body organs. Folk dietary remedies for dyspepsia included drinking peppermint tea or milk, eating spearmint leaves, or chewing mint-flavored chewing gum, which first became popular in the 1860s.
Although FD is not fully understood, there are several theories regarding its underlying mechanisms or possible causes:
The Rome criteria for FD specify that the patient must have had 12 weeks (not necessarily consecutively) of the following symptoms in the previous 12 months:
The Rome criteria specify three subtypes of FD based on the most bothersome symptom: ulcer-like dyspepsia (pain in the upper abdomen); dysmotility-like dyspepsia (an unpleasant but nonpainful feeling of bloating, fullness, or nausea); and unspecified dyspepsia (patient’s digestive discomfort does not fit either of the first two categories).
FD is widespread in the general population, however, the subtypes identified by the Rome working group appear to show slight gender differences. Ulcer-like dyspepsia appears to be more common in men and dysmotility-like dyspepsia more common in women. FD is equally widespread in all racial and ethnic groups.
Some medications other than aspirin and other over-the-counter pain relievers may cause dyspepsia: alendronate (Fosamax); codeine and aspirin fortified with codeine; iron supplements; metformin (Gluco-phage); oral antibiotics, particularly erythromycin; orlistat (Xenical); corticosteroids, especially predni-sone; and theophylline. Patients should consult their doctors before discontinuing these drugs or changing the dosage.
Patients with FD may also benefit from discontinuing certain herbal remedies that produce symptoms of dyspepsia. These include garlic, gingko, saw palmetto, feverfew, chaste tree berry, and willow bark.
Other treatments for functional dyspepsia include complementary and alternative (CAM) therapies and psychotherapy. CAM treatments include such herbal remedies as peppermint, turmeric, and aloe vera gel taken by mouth, and such non-dietary treatments as yoga, meditation, relaxation techniques, acupuncture, and music therapy. Psychotherapy is most likely to be helpful for patients with a history of abuse or post-traumatic stress as well as functional dyspepsia.
Prokinetic drugs may be prescribed for patients with dysmotility-like FD. These medications speed up or strengthen the contractions of the small intestine. Available medications include metoclopramide (Reglan), cisapride (Propulsid), and domperidone (Motilium). Domperidone is not approved for use in the United States because its adverse effects include abnormalities of heart rhythm. In addition to prokinetic drugs, some doctors prescribe antidepressant medications in order to lower the patient’s stress level and awareness of sensations coming from the stomach and intestines, but only a minority of patients with FD benefit from either proki-netics or antidepressants.
Medical management of FD in patients typically begins with either testing and treating the patient for infection with H. pylori or by prescribing medications to lower the level of stomach acid secretions for a trial period of 4–8 weeks. The two classes of medications most commonly prescribed to reduce acid secretion are H2-receptor blockers and proton pump inhibitors (PPIs). The first group, which is the older of the two, was developed in the late 1970s and early 1980s and includes such drugs as cimetidine (Tagamet) and rani-tidine (Zantac). The proton pump inhibitors are more powerful than the H2-receptor blockers and have fewer adverse effects. The PPIs include omeprazole (Prilosec), lansoprazole (Prevacid), esomeprazole (Nexium), pantoprazole (Protonix), and rabeprazole (Rabecid). In general, trial therapy with acid-reducing medications is considered more effective for FD than testing for and treating H. pylori infection, because only a small minority of patients with FD report.
improvement in their symptoms after treatment for the infection.
The function of medical and dietary treatment of FD is to manage or relieve the patient’s symptoms in order to improve his or her quality of life. Therapeutic fasting is intended to give the digestive system a brief period of rest prior to medication therapy or antibiotics to eradicate H. pylori Since the cause(s) of FD are not yet known for certain, these treatments cannot be considered cures.
The benefits of medical and dietary treatment of FD are improved symptom management and better quality of life, with less time lost from school or work.
Patients who experience dyspepsia for several weeks or longer should consult their physician for an evaluation to rule out more serious disorders; even if the indigestion is intermittent rather than continuous. Patients over age 45 who develop dyspepsia suddenly should see their doctor immediately, particularly if the indigestion is accompanied by black tarry stools, loss of appetite, painful swallowing, bloody vomit, or unintentional weight loss.
Patients who experience indigestion unrelated to eating, or indigestion accompanied by sweating, shortness of breath, or pain radiating to the neck, jaw, or arm should also see a doctor at once, as these symptoms may indicate a heart attack.
A population-based case-control study of adults in Minnesota found that there was no detectable difference in the consumption of frequently suspected culprit foods by patients with FD and the control subjects. There is also no evidence that a strictly vegetarian diet is useful in treating FD. Recent studies carried out in Germany indicate that a brief period of fasting under a doctor’s supervision is beneficial to patients with FD.
Research is ongoing to improve the number and effectiveness of treatment options for dyspepsia. In 2006, a new drug called itopride was tested for eight weeks on a group of 523 patients with functional dyspepsia. The drug requires further study, but the results of the initial trial are encouraging. Clinical trials sponsored by the National Institutes of Health are recruiting subjects to study medications or other forms of therapy for dyspepsia. They include studies of the effectiveness of acid-reducing therapy or eradication of H. pylori, and evaluation of food hyper-sensitivity in patients with dyspepsia.
In the field of CAM therapies, studies are being conducted of peppermint oil and turmeric as plant- or food-based treatments for dyspepsia. With regard to aloe vera, research indicates that it should not be taken by mouth as a remedy for dyspepsia because it has laxative qualities and can lower the body’s absorption of prescription medications. Other CAM approaches for dyspepsia being studied are mind/body approaches like relaxation training, yoga, and hypnosis, and energy therapies like acupuncture and therapeutic touch. European studies indicate that hydrotherapy and massage therapy are beneficial to patients with functional FD.
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American College of Gastroenterology (ACG). 6400 Goldsboro Road, Suite 450, Bethesda, MD 20817. Telephone: (301) 263-9000. Website: <http://www.acg.gi.org>
International Foundation for Functional Gastrointestinal Disorders (IFFGD). P.O. Box 170864, Milwaukee, WI 53217. Telephone: (888) 964-2001 or (414) 964-1799. Website: <http://www.iffdg.org>
National Center for Complementary and Alternative Medicine (NCCAM). 9000 Rockville Pike, Bethesda, MD 20892. Telephone: (888) 644-6226. Website: <http://nccam.nih.gov>
National Digestive Diseases Information Clearinghouse (NDDIC). 2 Information Way, Bethesda, MD 20892-3570. Telephone: (800) 891-5389. Website: <http://digestive.niddk.nih.gov/>
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). P.O. Box 6, Flourtown, PA 19031. Telephone: (215) 233-0808. Website: <http://www.naspghan.org>
U.S. Food and Drug Administration (FDA). 5600 Fishers Lane, Rockville, MD 20857-0001. Telephone: (888) INFO-FDA. Website: <http://www.fda.gov/>
Rebecca J. Frey, PhD